Null genotypes of glutathione S-transferase μ1 and glutathione S-transferase θ1 are associated with osteosarcoma risk: A meta-analysis
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منابع مشابه
Are glutathione S-transferase null genotypes "null and void" of risk for ischemic vascular disease?
The major risk factors for cardiovascular disease (CVD) relate to intrinsic changes in cholesterol metabolism or blood pressure regulation or to diseases such as diabetes. In addition, it has been found that chemical and pollutant exposure has adverse effects on cardiovascular health. Although we have known about the harmful effects of smoking on heart disease for a long time, recent research s...
متن کاملCombined glutathione S transferase M1/T1 null genotypes is associated with type 2 diabetes mellitus
BACKGROUND Due to new genetic insights, a considerably large number of genes and polymorphic gene variants are screened and linked with the complex pathogenesis of type 2 diabetes (DM). Our study aimed to investigate the association between the two isoforms of the glutathione S-transferase genes (Glutathione S transferase isoemzyme type M1- GSTM1 and Glutathione S transferase isoemzyme type T1-...
متن کاملGlutathione S-transferase polymorphisms in varicocele patients: a meta-analysis.
The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 control subjects. A systemati...
متن کاملGlutathione S-transferase M1 null genotype meta-analysis on gastric cancer risk
BACKGROUND Glutathione S-transferases (GSTs) have proved to be involved in the detoxifying several carcinogens and may play an important role in carcinogenesis of cancer. Previous studies on the association between Glutathione S-transferase M1 (GSTM1) polymorphism and gastric cancer (GC) risk reported inconclusive results. To get a precise result, we conducted this present meta-analysis through...
متن کاملGlutathione S-transferase activity and glutathione S-transferase mu expression in subjects with risk for colorectal cancer.
The glutathione S-transferases (alpha, mu, and pi), a family of Phase II detoxication enzymes, play a critical role in protecting the colon mucosa by catalyzing the conjugation of dietary carcinogens with glutathione. We investigated the efficacy of using the glutathione S-transferase (GST) activity of blood lymphocytes and GST-mu expression as biomarkers of risk for colorectal cancer. GST acti...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2015
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2015.2955